Harmful effects of transfusion of older stored red blood cells: iron and inflammation
نویسندگان
چکیده
منابع مشابه
TRANSFUSION MEDICINE Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation
1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY; 2New York Blood Center, NY; 3Caliper Life Sciences, Alameda, CA; 4Departments of Pediatrics and Medicine, Columbia University College of Physicians and Surgeons, New York, NY; 5AFLAC Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA; and 6Dep...
متن کاملTransfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.
Although red blood cell (RBC) transfusions can be lifesaving, they are not without risk. In critically ill patients, RBC transfusions are associated with increased morbidity and mortality, which may increase with prolonged RBC storage before transfusion. The mechanisms responsible remain unknown. We hypothesized that acute clearance of a subset of damaged, stored RBCs delivers large amounts of ...
متن کاملTransfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.
Transfusions of RBCs stored for longer durations are associated with adverse effects in hospitalized patients. We prospectively studied 14 healthy human volunteers who donated standard leuko-reduced, double RBC units. One unit was autologously transfused "fresh" (3-7 days of storage), and the other "older" unit was transfused after 40 to 42 days of storage. Of the routine laboratory parameters ...
متن کاملTRANSFUSION MEDICINE Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron
Departments of 1Pathology and Cell Biology and 2Pediatrics and Medicine, Columbia University College of Physicians and Surgeons–New York Presbyterian Hospital, New York, NY; 3New York Blood Center, New York, NY; 4Aflac Cancer Center and Blood Disorders Service, Children’s Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Atlanta, GA; and 5Department of Pathology and Laboratory M...
متن کاملAnemia and transfusion of red blood cells
The red cells transfusion is a mainstay in the treatment of anemic patients. These blood transfusions are not without risks. The risk-benefit profile for red cell transfusions to treat anaemia is uncertain, but they may contribute to adverse patient outcomes in some situations. The ability of a patient to tolerate anaemia depends on their clinical condition and the presence of any significant c...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2011
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2011.03096.x